ProteOn XPR36 Protein Interaction Array System

Model: 
Protein Interaction Array System
Supplier: 

Surface Plasmon Resonance (SPR) is a powerful state-of -the-art  molecular technique that enables the advance of measure of bimolecular interactions in real-time in a label-free environment. The PorteOn XPR36 instrument provides sensitive and accurate kinetic and steady-state real time data on the ability of a biomolecule of interest to interact with cognate surface immobilised binding partner. While the interactants is immobilised to the sensor surface (e.g a gold chip), the other is free in solution, and passed over the surface. The principle of SPR involves measuring the change in the mass of an optically active surface as a candidate ligand interacts with its cognate surface immobilised target. Biomolecular interaction analysis can thus be used to identify the binding of two or more interactants to each other, determine the affinity of the interactions, and measure the actual association and dissociation rates. Association and dissociation is measured in arbitrary units and displayed as binding curves for the interaction (sensogram) in real-time. This provides critical kinetic and equilibrium data which is required for the manipulation and advancement of any biomolecule (e.g a novel drug) form the bench side into small animal studies and ultimately human clinical trials. Label-free screening assays with SPR technology support the process of selecting drug and vaccine candidates with better efficacy and analysis can proceed in the microMolar to sub-nanoMolar range, making the research process more productive and increases the probability os success in preclinical and clinical studies.

Status: 
Available
Condition: 
New
Category: 
Other
Disciplines: 
Multidisciplinary-all biological sciences
Life Expectancy: 
10years
Location
Faculty: 
Witwatersrand Medical School/ HIV Pathogenesis Research Laboratory
Department: 
Molecular Medicine and Haematology
7th Floor
7 York Road Parktown
Johannesburg
2193

Contact Person/s

Name: Dr Maria Papathanasopoulos
Phone: +27 11-717-2618
Email: Maria.Papathanasopoulos@wits.ac.za
Estimated Cost and Availability
Internal: 
R1 000
Per Hour
External: 
R2 000
Per Hour
Time Spent Researching: 
80
Time Spent Teaching: 
10
Time Spent Other: 
10

Grantholder

Title: Prof
First Name: Maria Antonia
Last Name: Papathanasopoulos
Phone: +27 11-717-2618
Email: Maria.Papathanasopoulos@wits.ac.za
Funding Information
Equipment Price: 
R3,416,910
Year of Acquisition: 
2011