The Orbitrap Fusion Tribrid mass spectrometer offers high resolution mass accuracy and is of novel design, aimed specifically at whole proteome analysis. The Orbitrap technology utilized by the MS is state-of-the-art technology and allows for rapid and accurate quantitative analysis of whole cell or sub-cellular proteomes. The Orbitrap mass spectrometers have established themselves as the new analytical standard for research in proteomics and drug discovery. It particularly excels at whole-proteome analysis, fulfilling all the requirements of high resolution (450 000), mass accuracy and sensitivity necessary for rapid, comprehensive and accurate identification and quantitation of proteins and their post-translational modifications in complex sample mixtures. Coupled to a UPLC this mass spectrometer is ideal for proteomics applications which include label-free capabilities as well as labelled quantification methods. It is a versatile instrument that can be used in the fields of proteomics, metabolomics, lipidomics and drug discovery.