MicroCal Isothermal Titration Calorimeter (ITC) Isothermal Titration Calorimeter (ITC)
Microcalorimetry measures minute heat changes associated with intra- and intermolecular interactions. It provides a rapid, direct method for determining drug or ligand-target binding affinities, without the need for radiolabelling, immobilisation, or indirect spectroscopic methods. The VP-ITC system is an ultrasensitive isothermal titration calorimeter that uses a cell feedback network (CFB) to differentially measure and compensate for heat produced or absorbed between the sample and reference cell. A major advantage of the VP-ITC system is three users-selectable modes of operation: high gain, low gain and passive. The high gain mode is suggested for most ITC experiments, allowing the fastest re-equilibration between injections, thereby providing the shortest experimental times. The passive mode has the lowest noise, and is useful when examining very small signal changes in systems having slow transients.
Contact Person/s
Grantholder
First Name: EDS
Last Name: Sturrock
Phone: +27 21-406-6312
Email: edward.sturrock@uct.ac.za